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FLASH GENE

Symbol

CCNC

contributors: mct/ - updated : 28-09-2015

HGNC name	cyclin C
HGNC id	1581

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       highly Lymphoid/Immune thymus       highly Respiratory respiratory tract trachea     highly Urinary bladder       highly   kidney       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY	cyclin family
	cyclin c subfamily

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleoplasm

basic FUNCTION	regulating S transition of the cell cycle
	may play a role in transcriptional regulation
	important role of cyclin C (CCNC) in regulating human HSPC (hematopoietic stem/progenitor cells) quiescence

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

part of CDK8 subcomplex (containing CDK8, cyclin C, MED12, and MED13), functioning as a simple switch that controls the Mediator–pol II interaction to help regulate transcription initiation and reinitiation events (Knuesel 2009)

INTERACTION

DNA

RNA

small molecule

protein	interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II
	partner of cyclin-dependent kinase CDK3, CCNC controls cellular proliferation and, together with CDK8, represses gene transcription
	CDK8 associates with cyclin C (CCNC) and belongs to the CDK module of the Mediator of transcription, together with MED12 and MED13
	CDK8 is a regulatory partner of CCNC
	MTOR is a critical regulator of CDK8 and its activating partner CCNC
	CDK8 and its paralog CDK19, in complex with CCNC, MED12 and MED13, are transcriptional regulators that mediate several carcinogenic pathways and the chemotherapy-induced tumor-supporting paracrine network

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   LOH     highly frequent in osteosarcoma constitutional     --over   in Alzheimer disease (AD), suggesting different cellular functions in neurons and astrocytes in AD tumoral   deletion     in a subset of acute lymphoblastic leukemias

Susceptibility

Variant & Polymorphism

Candidate gene	candidate tumor suppressor gene in osteosarcoma
Marker
Therapy target

ANIMAL & CELL MODELS