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FLASH GENE
Symbol CCNC contributors: mct/ - updated : 28-09-2015
HGNC name cyclin C
HGNC id 1581
Location 6q16.2      Physical location : 99.990.263 - 100.016.690
Synonym name SRB11 homolog
Synonym symbol(s) CycC, hSRB11
DNA
TYPE functioning gene
STRUCTURE 26.59 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 2321 33.1 283 - 2009 1924013
12 - 2099 22.8 198 - 2009 1924013
  • may play a presently unexplored and important role in mammalian testis and probably is the one that is mainly implicated in cell cycle regulation
    		•
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Lymphoid/Immunethymus   highly
    Respiratoryrespiratory tracttrachea  highly
    Urinarybladder   highly
     kidney   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • cyclin family
  • cyclin c subfamily
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • regulating S transition of the cell cycle
  • may play a role in transcriptional regulation
  • important role of cyclin C (CCNC) in regulating human HSPC (hematopoietic stem/progenitor cells) quiescence
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of CDK8 subcomplex (containing CDK8, cyclin C, MED12, and MED13), functioning as a simple switch that controls the Mediator–pol II interaction to help regulate transcription initiation and reinitiation events (Knuesel 2009)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II
  • partner of cyclin-dependent kinase CDK3, CCNC controls cellular proliferation and, together with CDK8, represses gene transcription
  • CDK8 associates with cyclin C (CCNC) and belongs to the CDK module of the Mediator of transcription, together with MED12 and MED13
  • CDK8 is a regulatory partner of CCNC
  • MTOR is a critical regulator of CDK8 and its activating partner CCNC
  • CDK8 and its paralog CDK19, in complex with CCNC, MED12 and MED13, are transcriptional regulators that mediate several carcinogenic pathways and the chemotherapy-induced tumor-supporting paracrine network
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   LOH    
    highly frequent in osteosarcoma
    constitutional     --over  
    in Alzheimer disease (AD), suggesting different cellular functions in neurons and astrocytes in AD
    tumoral   deletion    
    in a subset of acute lymphoblastic leukemias
    Susceptibility
    Variant & Polymorphism
    Candidate gene candidate tumor suppressor gene in osteosarcoma
    Marker
    Therapy target
    ANIMAL & CELL MODELS