Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol POU3F2 contributors: mct/shn - updated : 05-07-2023
HGNC name POU class 3 homeobox 2
HGNC id 9215
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a POU-specific domain
  • an homeobox DNA-binding domain
    • mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies ortholog to Pou3f2, Mus musculus
    ortholog to Pou3f2, Rattus norvegicus
    ortholog to pou3f2, Danio rerio
    ortholog to POU3F2, Pan troglodytes
    intraspecies paralog to POU3F3
    Homologene
    FAMILY
  • POU transcription factor family
  • Class-3 subfamily
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • positively regulating the genes under the control of corticotropin-releasing hormone (CRM) and CRM II promoters
  • playing a role in mammalian neurogenesis by regulating their diverse patterns of gene expression
  • BRN2 and its phosphorylation are involved in the migration and proliferation of cells of the melanocyte lineage
  • POU3F3 and POU3F2 (Brn1 and Brn2) are known to label postmitotic upper-layer cells, and are redundantly required for their production
  • important for hypothalamic development and function, and controls oxytocin expression in the hypothalamic neuroendocrine preoptic area
  • plays an important role in brain development
  • is involved in cognitive function as well as adult hippocampal neurogenesis, and homopolymeric amino acid repeats in this gene play a functional role
  • importance of POU3F2 and MITF expression in development of melanoma metastasis (PMI: 28883623)
  • POU3F2, serving as an upstream factor, controls specification and differentiation of ganglionic eminences
    • CELLULAR PROCESS cell life, proliferation/growth
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development , nervous system
    text
  • neuronal development
  • positive regulation of cell proliferation
    • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
  • binding prefenrentially to the recognition sequence consisting of two distinct half sites (GCAT and TAAT), separated by a non-conserved spacer region of 0 or 2 or 3 nucleotides
  • binding to the octamer sequence ATGCAAAT
    • RNA
    small molecule
    protein
  • class III POU factor Brn-4
  • PQBP1
  • POU3F2, POU3F3 influence multiple stages of neurogenesis by suppressing Notch effector HES5, and promoting the expression of proneural transcription factors EOMES and TBR1
  • in the astrocyte lineage, ZBTB20 directly represses the expression of POU3F2, which encodes a protein necessary for upper-layer neuron specification
  • POU3F2 binds to the NTF3 promoter during neuronal differentiation
  • act downstream of SIM1 and interacts with the leptin and melanocortin pathway
    • cell & other
    REGULATION
    repressed by PQBP1
    Phosphorylated by PKA
    ASSOCIATED DISORDERS
    corresponding disease(s) NDDOTSA
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • BRN2AA transgene in a Mitf heterozygous background and in a Pax3 mutant background enhanced the coat color phenotype