Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

E2F3

contributors: mct/pgu - updated : 05-04-2016

HGNC name	E2F transcription factor 3
HGNC id	3115

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in retinoblastoma tumoral     --over   and amplified in invasively growing bladder cancer tumoral     --over   inactivation of the RB1 pathway is required in addition to E2F3 overexpression in bladder tumours tumoral     --over   in liver cancer tissues tumoral     --over   of KIF14 and E2F3 protein in retinoblastoma

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     E2F3-Aurora-A axis could be an important target for cancer intervention

ANIMAL & CELL MODELS