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FLASH GENE
Symbol E2F3 contributors: mct/pgu - updated : 05-04-2016
HGNC name E2F transcription factor 3
HGNC id 3115
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a DNA binding domain
  • a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins
  • putative leucine zippers
  • a carboxyterminal domain of interaction with pRB
    • HOMOLOGY
    Homologene
    FAMILY
  • E2F/DP family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • controlling genes regulating S phase entry and DNA synthesis
  • involved in transcription repression in quiescent cell by interaction with histone deacetylase
  • playing a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses
  • could exert a strong influence over the susceptibility to oncogenic transformation
  • regulate cell cycle-dependent gene expression through opposing transcriptional activating and repressing activities in growing and quiescent cells
  • have a critical role in modifying cellular proliferation rate in bladder and prostate cancer
  • mediator of DNA damage-induced apoptosis
  • induces apoptosis in Hepatocellular carcinoma cells and plays important roles in regulating transcription
  • E2F3 is an oncogene with strong proliferative potential and is regularly dysregulated or overexpressed in cancer
  • in contrast to E2F1 and E2F3, which sensitize to death, E2F4 plays a crucial protective role in neuronal death evoked by DNA damage, hypoxia, and global ischemic insult
    • CELLULAR PROCESS cell cycle
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds specifically to RB1 protein, in a cell-cycle dependent manner
  • p107 (RBL1), p130 (RBL2) binding
  • modulates Aurora-A mRNA expression during the cell cycle (directly binds to Aurora-A promoter and stimulates the promoter activity)
  • with E2F1 contribute to ATM-dependent phosphorylation of TP53 and apoptosis in cells expressing E1A
  • HELLS interacts with E2F3A and cooperates with its oncogenic functions
  • PUM1 and PUM2 repress the translation of E2F3 by binding to the E2F3 3prime untranslated region (UTR) and also enhance the activity of multiple E2F3 targeting microRNAs
  • TRIM28 has anti-proliferative activity in lung cancers via repression of E2F3, E2F4 that are critical for cell proliferation
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in retinoblastoma
    tumoral     --over  
    and amplified in invasively growing bladder cancer
    tumoral     --over  
    inactivation of the RB1 pathway is required in addition to E2F3 overexpression in bladder tumours
    tumoral     --over  
    in liver cancer tissues
    tumoral     --over  
    of KIF14 and E2F3 protein in retinoblastoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    E2F3-Aurora-A axis could be an important target for cancer intervention
    ANIMAL & CELL MODELS