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FLASH GENE

Symbol

RUNX2

contributors: mct - updated : 16-08-2020

HGNC name	runt-related transcription factor 2
HGNC id	10472

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ANIMAL & CELL MODELS

	Mice overexpressing Runx2 in osteoblasts have an abnormally low number of osteocytes in cortical bone
	Runx2-null mice die at birth lacking a mineralized skeleton, and are in a hypothyroid state
	Runx2 haploinsufficient mice mimic features of human cleidocranial dysplasia in that they present with hypoplastic clavicles and delayed cranial suture development with persistent fontanels in the calvaria