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FLASH GENE
Symbol NOTCH4 contributors: mct - updated : 28-05-2020
HGNC name Notch homolog 4 (Drosophila)
HGNC id 7884
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --low  
in endometrial cancer
constitutional     --over  
in proliferating hemangiomas
tumoral     --low  
in colorectal cancer (CRC), which could determine tumor proliferation, relapse, and prognosis
Susceptibility
  • schizophrenia (minor locus)
  • alopecia areata(ALPCA)
  • to rheumatoid arthritis
  • to variation of characteristics of migraine
    • Variant & Polymorphism SNP
  • A>G 5 utr,(CTG)10 alleles (exon 1)
  • variants in the NOTCH4 Gene influence the clinical features of migraine
    • Candidate gene
    Marker
  • NOTCH4 mRNA level could be an independent prognostic factor for both disease-free and overall survival of colorectal cancer (CRC) patients
    • Therapy target
    ANIMAL & CELL MODELS
  • Notch4 null mice exhibited slightly delayed vessel growth in the retina