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FLASH GENE
Symbol CD24 contributors: mct/pgu - updated : 11-07-2022
HGNC name CD24 molecule
HGNC id 1645
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in non small cell lung cancer is associated with adenocarcinoma histology and disease progression and cancer-related death, indicative of aggressive tumor behavior
tumoral     --low  
in squamous cell carcinoma of the head and neck
tumoral     --over  
in chordoma, a malignant primary tumor derived from notochordal cells
tumoral     --over  
in the herniated nucleus pulposus
tumoral        
expression of CD24 correlates with poor prognosis in a variety of carcinomas
constitutional     --low  
in preterm Preeclampsia cases, and could be linked to reduced immune tolerance in preeclampsia
tumoral     --over  
is more common in breast cancer than in corresponding normal tissue
Susceptibility
  • to multiple sclerosis (genetic modifier for susceptibility and progression)
  • to systemic lupus erythematosus (SLE)
  • Variant & Polymorphism
  • A57V allele
  • CD24 Ala57Val polymorphism may predispose to SLE incidence and can be linked to immunologic manifestations and production of autoantibodies in this disease
  • Candidate gene
    Marker
  • is a promising biomarker for autoimmune diseases
  • Therapy target
    SystemTypeDisorderPubmed
    cancerurinary 
    promising therapeutic target for antimetastatic therapy in bladder carcinoma
    cancerdigestiveliver
    identification of the TWIST2-CD24 signaling pathway provides a potential therapeutic approach to target cancer stem cells in HCCs
    cancer  
    therapeutic potential for CD24 blockade in cancer immunotherapy
    cancer  
    treatment strategy of tumors through targeting CD24 on the surface of tumor cells or SIGLEC10 on immune cells
    immunologyautoimmune 
    novel therapeutic target for autoimmune diseases
    cancerdigestiveliver
    CD24-SIGLEC10 interaction, may represent a therapeutic target in HCC patients
    ANIMAL & CELL MODELS