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FLASH GENE

Symbol

NFKBIL1

contributors: mct/npt - updated : 27-08-2013

HGNC name	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
HGNC id	7800

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

rheumatoid arthritis to systemic lupus erythematosus (SLE)and Sjögren's syndrome (SS) to the development of chronic Chagas' cardiomyopathy among Trypanosoma cruzi-infected individuals (CCC)

Variant & Polymorphism SNP	96452(T/A) increase the risk of rheumatoid arthritis
	+738C allele was associated with a more than twofold and threefold increase in the risk of SLE and SS respectively, relative to the +738T allele (Castiblanco 2008)
	-262A -62A was prevalent in patients with CCC (Ramasawmy 2008)

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS