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FLASH GENE
Symbol GRIK2 contributors: mlm/pgu - updated : 11-04-2019
HGNC name glutamate receptor, ionotropic, kainate 2
HGNC id 4580
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four transmembrane segments (4TM)
  • C-terminal domain may contain residue(s) involved in the PKA-mediated potentiation, and protein-protein interactions at the C-terminal domain are important for regulating kainate receptor physiology
    • mono polymer homomer , heteromer , tetramer
    HOMOLOGY
    interspecies homolog to murine Grik2 (98.4pc)
    homolog to rattus Grik2 (98.8pc)
    Homologene
    FAMILY
  • glutamate-gated ion channel (TC 1.A.10) family
  • GRIK2 subfamily
    • CATEGORY receptor membrane , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • may be involved in the transmission of light information from the retina to the hypothalamus
  • might be involved in the maturation of microcircuits and network formation in brain areas that are important for higher brain functions, such as the hippocampus
  • mediating facilitatory effects of kainate on mossy fiber synaptic transmission, important modulator of mossy fiber synaptic strength
  • modulating cell surface expression of NETO2
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling neurotransmission
    a component
  • four subunits fonctioning as ligand-activated ion channels
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with GRIK1 AND KIF17
  • interacting with DLG4 and NETO2
  • KLHL17 is able to bind to GRIK2, a kainate-type glutamate receptor subunit, and target GRIK2 for degradation
  • GRIK1, GRIK2, interact with the spectrin-actin binding scaffolding protein EPB41L1 through a membrane-proximal domain in the C-terminal tail
  • regulation of GRIK2 by SGK1 and NDRG2 in astrocytes may play an important role in gliotransmission, modulation of gene expression and regulation of exocytosis of tissue-type plasminogen activator (tPA)
  • TTBK2 down-regulates GRIK2 activity by decreasing the receptor protein abundance in the cell membrane via RAB5A-dependent endocytosis, an effect that may protect against neuroexcitotoxicity
    • cell & other
    REGULATION
    Other phosphorylation by PKC regulates endocytosis of GRIK2 at the plasma membrane
    sumoylated by PIAS3 and desumoylated by SENP1
    subject to RNA editing at multiple sites, which is thought to alter the structure and fonction of the receptor complex
    ASSOCIATED DISORDERS
    corresponding disease(s) MRT6
    Susceptibility
  • may be associated with susceptibility for obsessive-compulsive disorder
  • to chronic fatigue syndrome (CFS)
    • Variant & Polymorphism SNP
  • G allele of rs2247215 (GRIK2) were more likely to have CFS and CFS subjects showed decreased GRIK2 expression
    • Candidate gene
  • for AUTS18
  • may be involved in the excitotoxicity in the pathogenesis of Huntington disease
    • Marker
    Therapy target
    ANIMAL & CELL MODELS