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FLASH GENE

Symbol

CTNNA1

contributors: mct - updated : 21-02-2018

HGNC name	catenin (cadherin-associated protein), alpha 1, 102kDa
HGNC id	2509

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral somatic mutation     loss of function loss of function by somatic mutation in lung, prostate, ovarian colon cancer cell lines tumoral     --low   by hypermethylation, more common in AML patients with 5q deletion than those without 5q deletion tumoral fusion       with RAF1 in melanomas

Susceptibility

Variant & Polymorphism

Candidate gene	loss of expression of the alpha-catenin tumor suppressor in hematopoietic stem cells may provide a growth advantage that contributes to human MDS or AML with del(5q)
Marker
Therapy target

ANIMAL & CELL MODELS