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FLASH GENE
Symbol CTNNA1 contributors: mct - updated : 21-02-2018
HGNC name catenin (cadherin-associated protein), alpha 1, 102kDa
HGNC id 2509
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated PhosphoP
mono polymer homomer , monomer , dimer
HOMOLOGY
interspecies ortholog to rattus Catna1
ortholog to murine Ctnna1
homolog to zebrafish ctnna
intraspecies homolog to vinculin
Homologene
FAMILY
  • vinculin/alpha-catenin family
    • CATEGORY adhesion , structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,desmosome
        intracellular
    intracellular,cytoplasm,cytosolic
    text colocalizes with CTNNA1 at the intercalated discs of cardiomyocytes and in peritubular myoid cells of testis
    basic FUNCTION
  • regulating cell adhesion
  • playing a crucial role in cell differentiation
  • directly regulating actin-filament organization by suppressing Arp2/3-mediated actin polymerization
  • connecting cell-density-dependent adherens junctions with the developmental hedgehog pathway and providing a negative feedback loop controlling the size of developing cerebral cortex
  • associated with E-cadherin play a critical role in the regulation of cell-cell adhesion
  • key regulator of beta-catenin transcriptional activity and the status of CTNNA1 expression in prostatic tumor tissues might have prognostic value for SRC targeted therapy
  • forced expression of CTNNA1 in cancer cells can restore both higher intercellular avidity and intercellular E-cadherin bond strength
  • essential for the regulation of cell–cell and cell–matrix interactions in tissues
  • epithelial cells remodel their junctional architecture by responding to mechanical forces, and CTNNA1-bound LIMA1 acts as a mechanosensitive regulator for this process
  • plasticity of the CDH5-CTNNA1 complex is central for the leukocyte diapedesis mechanism
  • central role of CTNNA1 in global cytoskeleton remodelling, in which it acts not only on actin but also on MT reorganisation during epithelial morphogenesis
    • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    molecular pathway PTEN-CEBPA-CTNNA1 which is evolutionarily conserved, and controls myeloid development and transformation
    a component
  • constituent of the E cadherin multiprotein complex
  • constituent of desmosomal plaque
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MLLT4
  • F-actin
  • cadherin
  • vinculin
  • association of CTNNA1 with the cadherin-catenin complex is required for efficient leukocyte transendothelial migration
  • interacting with JNK (JNK affects the association of CTNNA1 with the adherens junction complex and regulates adherens junctions)
  • is the most common interaction partner of YAP1 in keratinocytes (is crucial for the inactivation of YAP1 in keratinocytes)
  • CTNNA1/CTNND1 contact within the cadherin-catenin complex can regulate cadherin trafficking
  • AJUBA associates with CTNNA1 and its localization to adherens junctions and association with CTNNA1 are promoted by cytoskeletal tension
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral somatic mutation     loss of function
    loss of function by somatic mutation in lung, prostate, ovarian colon cancer cell lines
    tumoral     --low  
    by hypermethylation, more common in AML patients with 5q deletion than those without 5q deletion
    tumoral fusion      
    with RAF1 in melanomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene loss of expression of the alpha-catenin tumor suppressor in hematopoietic stem cells may provide a growth advantage that contributes to human MDS or AML with del(5q)
    Marker
    Therapy target
    ANIMAL & CELL MODELS