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FLASH GENE

Symbol

CTNNA1

contributors: mct - updated : 21-02-2018

HGNC name	catenin (cadherin-associated protein), alpha 1, 102kDa
HGNC id	2509

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive intestine large intestine colon   highly Nervous brain       highly Reproductive female system breast mammary gland   highly   female system ovary     highly   female system uterus     highly Skin/Tegument skin       predominantly Urinary kidney       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone       Muscular striatum cardiac   highly Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Muscular myocyte

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

PhosphoP

mono polymer

homomer , monomer , dimer

HOMOLOGY

interspecies	ortholog to rattus Catna1
	ortholog to murine Ctnna1
	homolog to zebrafish ctnna

intraspecies

homolog to vinculin

Homologene

FAMILY

vinculin/alpha-catenin family

CATEGORY

adhesion , structural protein

SUBCELLULAR LOCALIZATION	plasma membrane,junction,desmosome
	intracellular
	intracellular,cytoplasm,cytosolic
text	colocalizes with CTNNA1 at the intercalated discs of cardiomyocytes and in peritubular myoid cells of testis

basic FUNCTION	regulating cell adhesion
	playing a crucial role in cell differentiation
	directly regulating actin-filament organization by suppressing Arp2/3-mediated actin polymerization
	connecting cell-density-dependent adherens junctions with the developmental hedgehog pathway and providing a negative feedback loop controlling the size of developing cerebral cortex
	associated with E-cadherin play a critical role in the regulation of cell-cell adhesion
	key regulator of beta-catenin transcriptional activity and the status of CTNNA1 expression in prostatic tumor tissues might have prognostic value for SRC targeted therapy
	forced expression of CTNNA1 in cancer cells can restore both higher intercellular avidity and intercellular E-cadherin bond strength
	essential for the regulation of cell–cell and cell–matrix interactions in tissues
	epithelial cells remodel their junctional architecture by responding to mechanical forces, and CTNNA1-bound LIMA1 acts as a mechanosensitive regulator for this process
	plasticity of the CDH5-CTNNA1 complex is central for the leukocyte diapedesis mechanism
	central role of CTNNA1 in global cytoskeleton remodelling, in which it acts not only on actin but also on MT reorganisation during epithelial morphogenesis

CELLULAR PROCESS	cell life, differentiation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

molecular pathway PTEN-CEBPA-CTNNA1 which is evolutionarily conserved, and controls myeloid development and transformation

a component	constituent of the E cadherin multiprotein complex
	constituent of desmosomal plaque

INTERACTION

DNA

RNA

small molecule

protein	MLLT4
	F-actin
	cadherin
	vinculin
	association of CTNNA1 with the cadherin-catenin complex is required for efficient leukocyte transendothelial migration
	interacting with JNK (JNK affects the association of CTNNA1 with the adherens junction complex and regulates adherens junctions)
	is the most common interaction partner of YAP1 in keratinocytes (is crucial for the inactivation of YAP1 in keratinocytes)
	CTNNA1/CTNND1 contact within the cadherin-catenin complex can regulate cadherin trafficking
	AJUBA associates with CTNNA1 and its localization to adherens junctions and association with CTNNA1 are promoted by cytoskeletal tension

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral somatic mutation     loss of function loss of function by somatic mutation in lung, prostate, ovarian colon cancer cell lines tumoral     --low   by hypermethylation, more common in AML patients with 5q deletion than those without 5q deletion tumoral fusion       with RAF1 in melanomas

Susceptibility

Variant & Polymorphism

Candidate gene	loss of expression of the alpha-catenin tumor suppressor in hematopoietic stem cells may provide a growth advantage that contributes to human MDS or AML with del(5q)
Marker
Therapy target

ANIMAL & CELL MODELS