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FLASH GENE

Symbol

CDSN

contributors: mct - updated : 26-08-2010

HGNC name	corneodesmosin
HGNC id	1802

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

HTSS1 , PSS

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --other   reduced degradation of all corneodesmosomal proteins in psoriatic lesions which probably reflects the persistence of corneodesmosomes (Simon 2008)

Susceptibility

psoriasis (PSORS1)

Variant & Polymorphism other	allele 971T confering psoriasis susceptibility
	rare allele (+1243)

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Cdsn-deficient mouse skin showed detachment of the stratum corneum from the underlying granular layer and/or detachment within the upper granular layers due to the disrupted integrity of the corneodesmosomes (Matsumoto 2008)