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FLASH GENE

Symbol

HSP90AB1

contributors: mct - updated : 23-04-2016

HGNC name	heat shock protein 90kDa alpha (cytosolic), class B member 1
HGNC id	5258

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_007355 12 - 2567 NP_031381 83.3 724 - 2005 16269234 HSP90AB1-1 NM_001271972 - - 2673 NP_001258901 - 714 amygdala 2005 16269234 HSP90AB1-2 NM_001271970 - - 2642 NP_001258899 - 724 colon 2005 16269234 HSP90AB1-3 NM_001271971 - - 2559 NP_001258900 - 676 pancreas 2005 16269234 HSP90AB1-4 NM_001271969 - - 2716 NP_001258898 - 724 - 2005 16269234

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       highly Reproductive female system ovary     highly   male system testis       Skin/Tegument skin       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow

cells

System Cell Pubmed Species Stage Rna symbol Reproductive spermatogonia

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an adenine nucleotide binding site
	a potential leucine zipper domain between two charged regions
	a binding site for steroid receptors and for the cochaperone Hop (hsp organizing protein) and hsp23
	a C terminal dimerization domain

mono polymer

homomer , dimer

HOMOLOGY

Homologene

FAMILY

heat shock protein 90 family

CATEGORY

chaperone/stress

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,cytosolic

basic FUNCTION	molecular chaperone, having ATPase activity
	involved in signaling prolactin-induced apoptosis through the receptor
	could be involved in human ovarian autoimmunity and thereby be a causative factor in early ovarian failure
	potential role for HSP90AB1 in mesenchymal stromal cells biology
	involved in BCL2-dependent stabilization of HIF-1alpha protein during hypoxia
	HSP90AA1, HSP90AB1 differentially modulate NO and O(2)(-) generation by eNOS (endothelial nitric oxide synthase) through promoting changes in endothelial nitric oxide synthase conformation and phosphorylation state 3)
	possible role for HSP90AB1 in postentry HIV replication
	potential role for this class of cellular chaperones in HIV core stability and uncoating
	may positively regulate angiogenesis, not only as a protein chaperone, but also as an mRNA stabilizer for pro-angiogenic genes, such as BCL6B, in a PRKD2 activity-dependent manner

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

BCAS2 can form a complex with AR and HSP90, it may function with HSP90AB1 to stabilise AR protein from being degraded by proteasome

INTERACTION

DNA

RNA

small molecule	nucleotide,
	ATP

protein	Hsp23 in an ATP dependent manner
	steroid receptors
	BIRC2 is a client protein of the stress protein HSP90AB1 (prevents auto-ubiquitination and degradation of BIRC2, whose depletion would be sufficient to inhibit cell differentiation)
	UNC45A is required for the normal cellular distribution of HSP90AB1, but not HSP90AA1
	RAF1, HSF1, CDC37, and MAP2K1 interacted with both HSP90AA1 and HSP90AB1, and the relative patterns of these interactions were not affected by heat shock 4)
	TRIM8 modulates translocation of phosphorylated STAT3 into the nucleus through interaction with HSP90AB1 and consequently regulates transcription of NANOG in embryonic stem cells
	HSP90AA1 and HSP90AB1, and not HSP90B1-GRP94 or TRAP1, are responsible for maintaining proper cellular levels of ARNTL protein (r
	SMYD2-dependent HSP90AB1 methylation promotes cancer cell proliferation by regulating the chaperone complex formation
	ERBB2 interact with the chaperone, HSP90AB1, and the calcium pump, ATP2B2, within specific plasma membrane domains that protrude from the cell surface

cell & other

REGULATION

inhibited by

caspase-8-dependent caspase-10 activation promoted UVB-induced cell apoptosis

Other

cleaved by activated caspase-10 under UVB irradiation

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in gastric cancer tumoral     --over   in lung cancer constitutional     --low   in acute spinal cord injury

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed immunology infectious   may provide an attractive target for therapeutic intervention in HIV infection

ANIMAL & CELL MODELS