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FLASH GENE
Symbol MOG contributors: npt/ - updated : 15-01-2007
HGNC name myelin oligodendrocyte glycoprotein
HGNC id 7197
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an Ig-like domain
  • two transmembrane segments (2TM)
    • conjugated GlycoP
    mono polymer homomer , heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • immunologlobulin superfamily
  • BNT/MOG subfamily
    • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • may be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • target of HOXD1 (TTTAATTGTA sequence is involved in HOXD1 binding to the MOG promoter but neighboring TAAT sites may also be needed) (Booth 2007)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • susceptibility to multiple sclerosis
  • to obsessive compulsive disorder
    • Variant & Polymorphism other
  • polymorphism associated to to obsessive compulsive disorder
  • IgG but not IgM antibody titers to native MOG were significantly higher in MS patients compared with different control groups with the highest prevalence in primary progressive MS patients
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS