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FLASH GENE

Symbol

MOG

contributors: npt/ - updated : 15-01-2007

HGNC name	myelin oligodendrocyte glycoprotein
HGNC id	7197

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain diencephalon amygdala       brain diencephalon hypothalamus       nerve cranial nerve       Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous central white matter     Nervous peripherous

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an Ig-like domain
	two transmembrane segments (2TM)

conjugated

GlycoP

mono polymer

homomer , heteromer , dimer

HOMOLOGY

Homologene

FAMILY	immunologlobulin superfamily
	BNT/MOG subfamily

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION

may be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

target of HOXD1 (TTTAATTGTA sequence is involved in HOXD1 binding to the MOG promoter but neighboring TAAT sites may also be needed) (Booth 2007)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

susceptibility to multiple sclerosis to obsessive compulsive disorder

Variant & Polymorphism other	polymorphism associated to to obsessive compulsive disorder
	IgG but not IgM antibody titers to native MOG were significantly higher in MS patients compared with different control groups with the highest prevalence in primary progressive MS patients

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS