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FLASH GENE

Symbol

GLP1R

contributors: mct/npt - updated : 23-04-2012

HGNC name	glucagon-like peptide 1 receptor
HGNC id	4324

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in gut and lung neuroendocrine tumors--in particular, in insulinomas (Korner 2007)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     novel molecular target for in vivo scintigraphy and targeted radiotherapy for a variety of GLP1 receptor-expressing tumors neurology neurodegenerative Parkinson/dementia Parkinsonism GLP1R agonists (Exendin4) may exert various useful actions in persons at high risk for stroke or with Parkinson disease, a hypothesis that is amenable to clinical testing cardiovascular atheroma   GLP1R agonists seem to have direct effects on the cells involved in the progression of atherosclerosis, such as endothelial cells or macrophages miscelleaneous vascular ischemic injury EX4, GLP1R agonists reduced intimal thickening after vascular injury diabete type 2   GLP1R agonists may help design new therapies for cardiovascular disease in patients with type 2 diabetes

ANIMAL & CELL MODELS