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FLASH GENE
Symbol HIST1H1T contributors: shn/npt - updated : 09-06-2009
HGNC name histone cluster 1, H1t
HGNC id 4720
PROTEIN
PHYSICAL PROPERTIES basic
STRUCTURE
motifs/domains
  • central, globular DNA-binding domain
  • a N terminal lysine-rich region
  • a C terminal region with oligopeptide repeats enriched in serine, proline lysine
  • a CDK consensus motif
    • conjugated RiboP
    HOMOLOGY
    interspecies homolog to C.elegans f22f1.1
    ortholog to Hist1h1t, Mus musculus
    ortholog to Hist1h1t, Rattus norvegicus
    Homologene
    FAMILY
  • histone H1 family
    • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • essential for the condensation of nucleosome chains into higher order structures
    • CELLULAR PROCESS cell cycle,division,meiosis
    nucleotide, chromatin organization, remodeling
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice lacking histone H1t are fertile and show normal spermatogenesis