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FLASH GENE
Symbol HIST1H1T contributors: shn/npt - updated : 09-06-2009
HGNC name histone cluster 1, H1t
HGNC id 4720
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis  specific
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivespermatocyte
cell lineage germinal cells: pachytene spermatocytes
cell lines
fluid/secretion
at STAGE
life cycle
PROTEIN
PHYSICAL PROPERTIES basic
STRUCTURE
motifs/domains
  • central, globular DNA-binding domain
  • a N terminal lysine-rich region
  • a C terminal region with oligopeptide repeats enriched in serine, proline lysine
  • a CDK consensus motif
    • conjugated RiboP
    HOMOLOGY
    interspecies homolog to C.elegans f22f1.1
    ortholog to Hist1h1t, Mus musculus
    ortholog to Hist1h1t, Rattus norvegicus
    Homologene
    FAMILY
  • histone H1 family
    • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • essential for the condensation of nucleosome chains into higher order structures
    • CELLULAR PROCESS cell cycle,division,meiosis
    nucleotide, chromatin organization, remodeling
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice lacking histone H1t are fertile and show normal spermatogenesis