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FLASH GENE
Symbol HIST1H1E contributors: mct - updated : 06-06-2018
HGNC name histone cluster 1, H1e
HGNC id 4718
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a globular DNA-binding domain
  • a N terminal lysine-rich region, and N-terminal domain of H1 is an important determinant of affinity and specificity of H1-chromatin interactions
  • a C terminal region with oligopeptide repeats enriched in serine, proline, lysine, and the long, lysine-rich C-terminal tail of HIST1H1E encompasses multiple regulatory residues that are substrates for cyclin-dependent kinases, and the extent of phosphorylation controls the proper compaction required for chromosome segregation, as well as local chromatin decondensation needed to promote DNA transcription, replication, and repair
    • HOMOLOGY
    interspecies homolog to C.elegans f22f1.1
    ortholog to murine Hist1h1e
    Homologene
    FAMILY
  • histone H1/H5 family
    • CATEGORY regulatory , DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome,nucleosome
    intracellular,nucleus,chromatin/chromosome,heterochromosome
    basic FUNCTION
  • involved in basal repression of gene expression
  • playing a role in the condensation of nucleosome chains into higher order structures
  • involved in epigenetic regulation
    • CELLULAR PROCESS nucleotide, chromatin organization, remodeling
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) OGID1
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS