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FLASH GENE

Symbol

HIST1H1E

contributors: mct - updated : 06-06-2018

HGNC name	histone cluster 1, H1e
HGNC id	4718

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
text	clustered with core histone genes
STRUCTURE	0.78 kb     1 Exon(s)    1 Copie(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter (CAAT box) (TATA box)
text structure	highly conserved H1/AC box

MAPPING

cloned

Y

linked

N

status

confirmed

regionally located

in the large histone gene cluster

RNA

TRANSCRIPTS	type	messenger

text	lacking the polyA tail but having instead a palindromic termination element

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005321 1 - 785 NP_005312 21.7 219 - 2016 26689747

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a globular DNA-binding domain
	a N terminal lysine-rich region, and N-terminal domain of H1 is an important determinant of affinity and specificity of H1-chromatin interactions
	a C terminal region with oligopeptide repeats enriched in serine, proline, lysine, and the long, lysine-rich C-terminal tail of HIST1H1E encompasses multiple regulatory residues that are substrates for cyclin-dependent kinases, and the extent of phosphorylation controls the proper compaction required for chromosome segregation, as well as local chromatin decondensation needed to promote DNA transcription, replication, and repair

HOMOLOGY

interspecies	homolog to C.elegans f22f1.1
	ortholog to murine Hist1h1e

Homologene

FAMILY

histone H1/H5 family

CATEGORY

regulatory , DNA associated , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,chromatin/chromosome,nucleosome
	intracellular,nucleus,chromatin/chromosome,heterochromosome

basic FUNCTION	involved in basal repression of gene expression
	playing a role in the condensation of nucleosome chains into higher order structures
	involved in epigenetic regulation

CELLULAR PROCESS	nucleotide, chromatin organization, remodeling
	nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

OGID1

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS