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FLASH GENE

Symbol

HIST1H1C

contributors: npt - updated : 20/11/2008

HGNC name	histone cluster 1, H1c
HGNC id	4716

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	0.78 kb     1 Exon(s)    1 Copie(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter (CAAT box) (TATA box)
text structure	highly conserved H1/AC box

MAPPING

cloned

Y

linked

N

status

confirmed

regionally located

in the large histone gene cluster

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed HIST1H1C 1 - 732 21.2 213 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES		basic
STRUCTURE

motifs/domains	a globular DNA-binding domain
	a N terminal lysine-rich region
	a C terminal region with oligopeptide repeats enriched in serine, proline, lysine

HOMOLOGY

interspecies	homolog to murine H1f2
	homolog to C.elegans m163.3

Homologene

FAMILY

histone H1/H5 family

CATEGORY

regulatory , DNA associated , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	involved in basal repression of gene expression
	playing a role in the condensation of nucleosome chains into higher order structures

CELLULAR PROCESS	nucleotide, chromatin organization, remodeling
	nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS