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FLASH GENE
Symbol HIST1H1A contributors: npt - updated : 20/11/2008
HGNC name histone cluster 1, H1a
HGNC id 4715
PROTEIN
PHYSICAL PROPERTIES basic
STRUCTURE
motifs/domains
  • a globular DNA-binding domain
  • a N terminal lysine-rich region
  • a C terminal region with oligopeptide repeats enriched in serine, proline, lysine
    • HOMOLOGY
    interspecies homolog to C.elegans f22f1.1
    homolog to murine Hist1h1a
    Homologene
    FAMILY
  • histone H1/H5 family
    • CATEGORY regulatory , DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in basal repression of gene expression
  • playing a role in the condensation of nucleosome chains into higher order structures
  • modulating the potentiation/depotentiation of chromatin structure for transcription
    • CELLULAR PROCESS nucleotide, chromatin organization, remodeling
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS