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FLASH GENE

Symbol

SLC6A3

contributors: mct - updated : 20-04-2020

HGNC name	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
HGNC id	11049

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ANIMAL & CELL MODELS

	mice lacking SLC6A3 protein have elevated dopaminergic tone and are hyperactive, with a decrease in locomotion in response to psychostimulants
	SLC6A3 null mice with pharmacologic inhibition of tyrosine hydroxylase demonstrated severe akinesia, rigidity, tremor and psotis similar to behaviors observed in patients with Parkinson Disease. L-dopa temporarily restored locomotion and amphetamines deriatives showed effectiveness in reducing motor abnormalities