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FLASH GENE
Symbol TPM3 contributors: mct/npt - updated : 21-09-2016
HGNC name tropomyosin 3
HGNC id 12012
Corresponding disease
CFTD3 congenital fibre type disproportion 3
NEM1 nemaline myopathy 1
Location 1q21.3      Physical location : 154.127.779 - 154.164.609
Synonym name
  • non muscle tropomyosin 5
  • tropomyosin gamma
  • cytoskeletal tropomyosin TM30
  • heat-stable cytoskeletal protein 30 kDa
  • tropomyosin alpha-3 chain
  • Synonym symbol(s) TRK, TC22, MGC14582, MGC3261, MGC72094, FLJ41118, TM-5, TM3, TM30, TM30nm, hscp30, Tm5NM-1
    DNA
    TYPE functioning gene
    STRUCTURE 30.32 kb     10 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    text structure one alternative non muscle form lacking 2 exon
    MAPPING cloned Y linked N status provisional
    Physical map
    S100A2 1q21 S100 calcium binding protein A2 S100A1 1q21 S100 calcium binding protein A1 DKFZP547E1010 1q22 DKFZP547E1010 protein SNAPAP 1q22 SNAP-associated protein ILF2 1q21.1 interleukin enhancer binding factor 2, 45kDa NPR1 1q21.1 natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A) FLJ21919 1q22 hypothetical protein FLJ21919 SLC27A3 1q21.1 solute carrier family 27 (fatty acid transporter), member 3 LOC343052 1q22 similar to putative neuronal cell adhesion molecule P66beta 1q22 transcription repressor p66 beta component of the MeCP1 complex KIAA0476 1p36.13-q31.3 transcription repressor p66 beta component of the MeCP1 complex LOC200186 1q22 hypothetical protein LOC200186 SLC39A1 1q21 solute carrier family 39 (zinc transporter), member 1 CREB3L4 1q21.2 cAMP responsive element binding protein 3-like 4 JTB 1q21 jumping translocation breakpoint RAB13 12q13 RAB13, member RAS oncogene family RPS27 1q21 ribosomal protein S27 (metallopanstimulin 1) LOC91181 1q22 nuclear pore membrane glycoprotein 210-like TPM3 1q22-q23 tropomyosin 3 LOC388701 1 LOC388701 NICE-3 1q21.2 NICE-3 protein NICE-4 1q22 NICE-4 protein HAX1 1q21 NICE-4 protein AQP10 1q21.2 aquaporin 10 ATP8B2 1q21.2 ATPase, Class I, type 8B, member 2 MRPS33P1 1q21.3 mitochondrial ribosomal protein S33 pseudogene 1 LOC388702 1 similar to 40S ribosomal protein SA (P40) (34/67 kDa laminin receptor) (Colon carcinoma laminin-binding protein) (NEM/1CHD4) (Multidrug resistance-associated protein MGr1-Ag) IL6R 1q21 interleukin 6 receptor LOC388703 1 similar to hypothetical protein 9430022A14 DKFZp434M202 1q22 hypothetical protein DKFZp434M202 UBE2Q 1q22 ubiquitin-conjugating enzyme E2Q (putative) CHRNB2 1q21.3 cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) ADAR 1q21.1-q21.2 adenosine deaminase, RNA-specific
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing - - - colon cancer cells and polyps with mild and severe dyasplasia Lin
    8 - 4539 28.8 247 - Ewing (2007)
    8 - 3212 28.9 248 - Ewing (2007)
    8 - 3212 - 248 - Ewing (2007)
    8 - 4539 - 247 - Ewing (2007)
    - - 7116 32.8 285 - Ewing (2007)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemprostate  highly
    Respiratoryrespiratory tractlarynx  highly
    Visualeyeanterior segmentcornea  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer dimer
    HOMOLOGY
    Homologene
    FAMILY
  • tropomyosin family
  • CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microfilament
    basic FUNCTION
  • playing a central role in association with the troponin complex, in the calcium dependent regulation of vertebrate striated
  • having functions in regulating cell motility and in modulating the anti-angiogenic activity of cleaved high molecular weight kininogen (HKa)(Jin 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text slow type I muscle fibers
    PATHWAY
    metabolism
    signaling
    a component
  • dimerizing to form a helical coiled coil constituent binding to actin in the troponin complex (thin filamant) that regulates calcium-dependent binding of actin and myosin and muscle contraction
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ACTA1 and TNNT1 and ultimatily regulating the development of muscle contraction
  • TTC9 interacts specifically with actin-binding protein tropomyosin TPM3 which stabilizes actin filament and focal adhesion
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NEM1 , CFTD3
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    fusion with NTRK1 in papillary thyroid carcinoma, with ALK in anaplastic large cell lymphoma
    tumoral fusion      
    with PDGFRB in chronic eosinophilic leukemia (Rosati 2006)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • serum anti-TPM3, anti-TMOD3, anti-STOML2 could be new markers for the early diagnosis of endometriosis
  • Therapy target
    ANIMAL & CELL MODELS
    Tm slow (Met 9Arg) mice