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FLASH GENE

Symbol

TCF19

contributors: KTN/npt - updated : 21/11/2008

HGNC name	transcription factor 19 (SC1)
HGNC id	11629

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 4 splicing 3306 37.1 345 - - variant 2 4 splicing 3060 37.1 345 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       highly   intestine       moderately Endocrine adrenal gland       moderately Lymphoid/Immune lymph node       moderately   thymus       highly Reproductive female system uterus cervix   moderately   male system prostate     moderately Urinary kidney       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     moderately

cell lineage
cell lines
fluid/secretion	moderately in blood and highly in lymph

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an FHA domain
	a PHD-type zinc finger

HOMOLOGY

interspecies	homolog to dog TCF19 (85.5 pc)
	homolog to cow TCF19 (85.8 pc)
	homolog to rattus Tcf119 (81.8 pc)
	homolog to murine Tcf19 (80.5 pc)

Homologene

FAMILY

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION

acting as a potential trans-activating factor that could play an important role in the transcription of genes required for the later stages of cell cycle progression

CELLULAR PROCESS	cell life, proliferation/growth
	nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	Zn2+

protein

cell & other

REGULATION

Other	growth regulated
	phosphorylated upon DNA damage, probably by ATM or ATR

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS