Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

Home Page

FLASH GENE

Symbol

IFNGR1

contributors: mct - updated : 05-09-2017

HGNC name	interferon gamma receptor 1
HGNC id	5439

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

IMD27A

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional   deletion     deletion/insertion polymorphism in Africans but not Europeans or Asians, and associated with resistance to severe malaria.

Susceptibility

to H. pylori infection schistosomal hepatic fibrosis to malaria to tuberculosis (TB) to mycobacterial disease

Variant & Polymorphism SNP , insertion/deletion , other	IFNGR1-56T and IFNGR1-470ins/del associated with susceptibility to malaria
	genetic polymorphisms in the promoter of IFNGR1 gene are associated with atopic cataracts
	certain genetic variants in IFNGR1 genes may be associated with TB development
	paternal uniparental isodisomy of chromosome 6 causing mycobacterial disease suceptibility with primary immunodeficiency

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS