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FLASH GENE

Symbol

HLA-F

contributors: mct - updated : 25-10-2018

HGNC name	major histocompatibility complex, class I, F
HGNC id	4963

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   as the menstrual cycle progresses and is upregulated by progesterone, PGR, and GATA2 during the differentiation of ESFs into DSCs and dysregulation is associated with implantation failure and recurrent spontaneous abortion

Susceptibility

to variation of fecundability

Variant & Polymorphism SNP	SNP rs2523393, which is an eQTL for HLA-F, is significantly associated with fecundability

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS