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FLASH GENE

Symbol

HLA-E

contributors: npt/ - updated : 23-05-2003

HGNC name	major histocompatibility complex, class I, E
HGNC id	4962

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed HLA-E 8 - 1701 38 358 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

cells

System Cell Pubmed Species Stage Rna symbol Skin/Tegument keratinocyte

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo, pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	three globular extracellular domains, alpha 1 and alpha 2 forming the peptide binding groove
	a I, C-like alpha 3 domain
	a single transmembrane domain
	a cytoplasmic tail

mono polymer

heteromer , dimer

isoforms

Precursor

HOMOLOGY

Homologene

FAMILY

HLA, class I family

CATEGORY

antigen

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane

basic FUNCTION	harboring structural features conferring tight peptide binding specificity correlating with the binding of an MHC class I leader peptide
	central immunotolerance role during early pregnancy, modulating cytokine production of monocyte-generated dendritic cells during early pregnancy

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense , reproduction/sex

text	required for the development of pregnancy

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

binding a restricted subset of peptides derived from the leader peptides of other class I molecules

cell & other

REGULATION

Other

TAP and tapasin dependent

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS