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FLASH GENE
Symbol HLA-DRA contributors: mct - updated : 21-04-2008
HGNC name major histocompatibility complex, class II, DR alpha
HGNC id 4947
Location 6p21.3      Physical location : 3.668.486 - 32.412.821
Genatlas name HLA-DR, alpha chain
Synonym name MHC cell surface glycoprotein
Synonym symbol(s) DASS-397D15.1, HLA-DRA1
DNA
TYPE functioning gene
STRUCTURE 5.00 kb     5 Exon(s)
MAPPING cloned Y linked Y status confirmed
Physical map
CREBL1 6p21.3 cAMP responsive element binding protein-like 1 FKBPL 6p21.3 FK506 binding protein like C6orf31 6p21.1 chromosome 6 open reading frame 31 PPT2 6p21.3 palmitoyl-protein thioesterase 2 EGFL8 6p21.31 EGF-like-domain, multiple 8 AGPAT1 6p21.3 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha) RNF5 6p21.31 ring finger protein 5 AGER 6p21.3 advanced glycosylation end product-specific receptor PBX2 6p21.3 pre-B-cell leukemia transcription factor 2 C6orf9 6p21.3 chromosome 6 open reading frame 9 NOTCH4 6p21.3 Notch homolog 4 (Drosophila) C6orf10 6p21.3 chromosome 6 open reading frame 10 BTNL2 6p21.3 butyrophilin-like 2 (MHC class II associated) HLA-DRA 6p21.3 major histocompatibility complex, class II, DR alpha HLA-DRB9 6p21.3 major histocompatibility complex, class II, DR beta 9 (pseudogene) HLA-DRB3 6p21.3 major histocompatibility complex, class II, DR beta 3 HLA-DRB2 6p21.3 major histocompatibility complex, class II, DR beta 2 HLA-DRB1 6p21.3 major histocompatibility complex, class II, DR beta 1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 1267 - 254 - Hafler (2007)
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node   highly
 tonsils   highly
Respiratoryrespiratory tractlarynx  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a leader peptide,
  • two extracellular domains,
  • a transmembrane domain and a cytoplasmic tail
  • mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION plays a central role in the immune system by presenting peptides derived from extracellular proteins
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component heterodimer consisting of an alpha and a beta chain
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS