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FLASH GENE
Symbol HLA-DPB1 contributors: npt/ - updated : 19-05-2006
HGNC name major histocompatibility complex, class II, DP beta 1
HGNC id 4940
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two extracellular globular domains
  • alpha 1, alpha 2, a transmembranee segment
  • a cytoplasmic tail, highly polymorphic
    • conjugated GlycoP
    mono polymer heteromer , dimer
    isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY
  • MHC class II family
    • CATEGORY antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic,vesicle
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimerizing with HLA-DPA1, forming the peptide groove between alpha 1 and beta 1 domains
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) WG
    Susceptibility
    Variant & Polymorphism other *0401 allele is strongly associated with WG in ANCA-positive subjects
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS