Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol HLA-DPB1 contributors: npt/ - updated : 19-05-2006
HGNC name major histocompatibility complex, class II, DP beta 1
HGNC id 4940
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 11.22 kb     6 Exon(s)
MAPPING cloned Y linked Y status confirmed
regionally located approximatively 130kb telomeric to RXRB with significant desiquilibrium between RXRB and HLA-DPB1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 1501 26.2 258 - -
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunedendritic cell
Lymphoid/Immunemacrophage
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two extracellular globular domains
  • alpha 1, alpha 2, a transmembranee segment
  • a cytoplasmic tail, highly polymorphic
    • conjugated GlycoP
    mono polymer heteromer , dimer
    isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY
  • MHC class II family
    • CATEGORY antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic,vesicle
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimerizing with HLA-DPA1, forming the peptide groove between alpha 1 and beta 1 domains
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) WG
    Susceptibility
    Variant & Polymorphism other *0401 allele is strongly associated with WG in ANCA-positive subjects
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS