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FLASH GENE

Symbol

HLA-B

contributors: mct/npt - updated : 19/11/2008

HGNC name	major histocompatibility complex, class I, B
HGNC id	4932

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

ankylosing spondylitis (AS) Behcet's disease to psoriasis arthropathy

Variant & Polymorphism other	interaction between KIR3DS1 and HLA-B (BW4-80Ile) decreases progression of HIV1
	HLA-B51 associated to Behcet's disease
	HLA-B27 associated to ankylosing spondylitis (may arise because of aberrant folding of HLA-B27 molecules within the ER)
	HLA-B51 may play a role in the pathogenesis of psoriasis arthropathy
	linkage to the HLA-B region in one AS pedigree (Gu 2009)

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS