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FLASH GENE
Symbol HARS contributors: mct - updated : 26-11-2010
HGNC name histidyl-tRNA synthetase
HGNC id 4816
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one WHEP-TRS domain
    • HOMOLOGY
    Homologene
    FAMILY
  • class-II aminoacyl-tRNA synthetase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins
  • catalyzing the transfer of the aminoacyl moiety from histidyl-adenylate to the terminal adenosine (A76) of tRNA
  • key role for histidyl-tRNA synthetase in the pathogenesis of idiopathic inflammatory myopathy
  • can likely trigger both innate and adaptive immune responses that culminate in severe muscle inflammation that is the hallmark of idiopathic inflammatory myopathy
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by tRNA aminoacylation activity of HARS appeared to be increased upon oxidative modification
    ASSOCIATED DISORDERS
    corresponding disease(s) CMT2W , USH3B
    Susceptibility to rheumatoid arthritis
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS