Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol HARS contributors: mct - updated : 26-11-2010
HGNC name histidyl-tRNA synthetase
HGNC id 4816
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver    
Endocrinethyroid    
Nervousbrain    
 ganglia    
Reproductivefemale systembreastmammary gland  
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one WHEP-TRS domain
    • HOMOLOGY
    Homologene
    FAMILY
  • class-II aminoacyl-tRNA synthetase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins
  • catalyzing the transfer of the aminoacyl moiety from histidyl-adenylate to the terminal adenosine (A76) of tRNA
  • key role for histidyl-tRNA synthetase in the pathogenesis of idiopathic inflammatory myopathy
  • can likely trigger both innate and adaptive immune responses that culminate in severe muscle inflammation that is the hallmark of idiopathic inflammatory myopathy
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by tRNA aminoacylation activity of HARS appeared to be increased upon oxidative modification
    ASSOCIATED DISORDERS
    corresponding disease(s) CMT2W , USH3B
    Susceptibility to rheumatoid arthritis
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS