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FLASH GENE

Symbol

GLO1

contributors: mct - updated : 06-11-2010

HGNC name	glyoxalase I
HGNC id	4323

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   amplification     in breast cancer, small cell lung cancer, acute myeloid leukemia, sarcoma tumoral     --over   in melanomas constitutional     --low   observed in major depressive and bipolar disorder patients in a current depressive state, as compared with healthy control subjects tumoral     --over   in kidney tumors

Susceptibility

to autism to breast cancer

Variant & Polymorphism SNP , other	C419A is a predisposing factor for autism
	Glu111Ala polymorphism associated with breast cancer

Candidate gene
Marker
Therapy target	may represent a useful target for therapy in cancers with GLO1 amplification

ANIMAL & CELL MODELS