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FLASH GENE

Symbol

GLO1

contributors: mct - updated : 06-11-2010

HGNC name	glyoxalase I
HGNC id	4323

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006708 6 - 2071 NP_006699 20.8 184 - 1999 10564821

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain midbrain substantia nigra     Reproductive male system prostate       Skin/Tegument skin

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

homomer , dimer

HOMOLOGY

Homologene

FAMILY

glyoxalase I family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
text	enzyme present in cytosol

basic FUNCTION	involved in the detoxification of methylglyoxal
	responsible for the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and reduced glutathione
	antioxidant enzyme which detoxifies alpha-ketoaldehydes to prevent the accumulation of pro-oxidant compounds, such as methylglyoxal, in all cell types
	its activity is required for osteoclastogenesis
	catalyzes the conversion of reactive alpha-oxoaldehydes to corresponding alpha-hydroxyacids
	cellular defense enzyme involved in the detoxification of methylglyoxal, a cytotoxic byproduct of glycolysis
	may have a function in the regulation of detoxification and target adduction by the glycolytic by product methylglyoxal in malignant melanoma

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

carbohydrate

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	one zinc ion per molecule

protein

methyl-gerfelin (M-GFN) targets GLO1, resulting in the inhibition of osteoclastogenesis

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   amplification     in breast cancer, small cell lung cancer, acute myeloid leukemia, sarcoma tumoral     --over   in melanomas constitutional     --low   observed in major depressive and bipolar disorder patients in a current depressive state, as compared with healthy control subjects tumoral     --over   in kidney tumors

Susceptibility

to autism to breast cancer

Variant & Polymorphism SNP , other	C419A is a predisposing factor for autism
	Glu111Ala polymorphism associated with breast cancer

Candidate gene
Marker
Therapy target	may represent a useful target for therapy in cancers with GLO1 amplification

ANIMAL & CELL MODELS