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| CX43 mutant embryos died at birth as a result of a failure in pulmonary gas exchange caused by a swelling and blockage of the right ventricular outflow tract from the hear | |
mice homozygous for CX43 exhibit an abnormal cardiac morphogenetic process |
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lack of expression of CX43 during embryogenesis compromising terminal stages of primary T and B cells differentiation |
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Blood pressure and heart rate measurements were significantly lower in the Cx43 knockout mice |
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mice lacking the C-terminal region of connexin-43 died shortly after birth. Female mice lacking the C-terminal region of connexin-43 are infertile due to impaired folliculogenesis |
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mouse model of ODDD (heterozygous for the human I130T mutation) showed a reduced Cx43 expression in hearts with preferential loss of phosphorylated forms, resulting in interference with trafficking and with assembly of gap junctions in the junctional membrane |
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adult Sertoli cell-specific Cx43 knockout (SC-Cx43 KO) mice displayed spermatogenic arrest at the spermatogonial level  |