| protein
| tight junction protein 1, TJP1 (Giepmans et al, 1998) |
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TJP1 and gap junction protein, gamma 1, 45kDa (GJC1) in osteoblastic cells  |
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gap junction protein alpha 3 46kDa, GJA3 |
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gap junction protein alpha 5 40kDa, GJA5 |
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caveolin 1 caveolae protein 22kDa, CAV1 |
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casein kinase 1, CK1 |
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mitogen-activated protein kinase 7, MAPK7 |
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nephroblastoma overexpressed gene, NOV |
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connexin 43-interacting protein, 150kD (CIP150) |
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Cx43-interacting protein of 85-kDa, CIP85 |
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desmosomal protein PKP2 (form a protein complex within the desmosome-like junction to regulate cell adhesion at the blood–testis barrier, partly through its effects on the occludin/ZO-1 complex, so as to facilitate the transit of primary preleptotene spermatocytes) |
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interacting with ERP29 (new role for ERP29 as a chaperone that helps stabilize monomeric GJA1 to enable oligomerization to occur in the Golgi apparatus) |
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binding of the growth regulator CCN3 (NOV) at the C-terminus of GJA1 |
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TBX18 directly represses the GJA1 promoter |
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is a downstream target molecule of NONO |
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can regulate GJA1 expression at the transcription level and decreases in POR reduce gap junctional intercellular communication, as well as hemichannel activity |
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TCF12 functions as a regulator of EMT by affecting the expression of CDH1 as well as that of GJA1 and GJB2 |
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GJA1-mediated GJB1 and SLC1A5 interaction play important functional roles in trophoblast cell fusion |
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CASK directly interacts with GJA1 |
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integrin alpha5beta1 interacts directly with GJA1 and this interaction is required for mechanical stimulation-induced opening of the GJA1 hemichannel |
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both SENP1 and -2 induce deSUMOylation of GJA1 |
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regulates the passage of migrating neurons through their multipolar stage via CDKN1B signaling |
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MAPK-phosphorylated GJA1 is a novel interacting partner of cyclin E in VSMC (vascular smooth muscle cells) and this interaction is critical for VSMC proliferation |
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in the context of apoptosis, translocated to the mitochondria, where it interacted with BAX to initiate the mitochondrial apoptotic pathway |
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associates with SCN5A in the cardiomyocyte perinexus |
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NR1D1 activates GJA1 transcription by forming a complex with SP1 |
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CTTNBP2NL dephosphorylated GJA1 |
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oocyte-derived BMP15 decreases GJA1 activity between human granulosa cells by down-regulating Cx43 expression, most likely via a Smad-dependent signaling pathway |
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PPP2R2A is required for GJA1 dephosphorlyation during epidermal barrier acquisition |
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interaction between the T-cell protein tyrosine phosphatase (PTPN2) and the C-terminus of connexin43 (GJA1) |
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PRKAA1 stimulates ubiquitination of the gap junction protein GJA1, thereby contributing to gap junction remodeling following pressure overload |
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intermittent hypoxia causes reductions and remodeling of atrial GJA5, GJA1, generated in response to reactive oxygen species |
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by CYBB, and likely contributing to the substrate for atrial fibrillation that develops in response to obstructive sleep apnea |
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EXOSC10 was likely required for CELF1-mediated GJA1 mRNA degradation |
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EZR-anchored PRKACA phosphorylates serine 369 and 373 on GJA1 to enhance gap junction assembly, communication, and cell fusion |
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absence of CLMP caused a severe reduction of GJA1, GJC1 in smooth muscle cells of the intestine and of GJA1 in the ureter |
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GJA1 controls neural crest cell migration by directly regulating CDH2 transcription |
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| CX43 mutant embryos died at birth as a result of a failure in pulmonary gas exchange caused by a swelling and blockage of the right ventricular outflow tract from the hear | |
mice homozygous for CX43 exhibit an abnormal cardiac morphogenetic process |
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lack of expression of CX43 during embryogenesis compromising terminal stages of primary T and B cells differentiation |
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Blood pressure and heart rate measurements were significantly lower in the Cx43 knockout mice |
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mice lacking the C-terminal region of connexin-43 died shortly after birth. Female mice lacking the C-terminal region of connexin-43 are infertile due to impaired folliculogenesis |
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mouse model of ODDD (heterozygous for the human I130T mutation) showed a reduced Cx43 expression in hearts with preferential loss of phosphorylated forms, resulting in interference with trafficking and with assembly of gap junctions in the junctional membrane |
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adult Sertoli cell-specific Cx43 knockout (SC-Cx43 KO) mice displayed spermatogenic arrest at the spermatogonial level |
