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FLASH GENE

Symbol

FGF1

contributors: mct/pgu - updated : 12-04-2016

HGNC name	fibroblast growth factor 1 (acidic)
HGNC id	3665

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       loss of function results in diet-induced insulin resistance

Susceptibility

to intracranial aneurysm to Alzheimer disease(AD) to variation of systolic Blood pressure

Variant & Polymorphism SNP	SNP at intron 4 increasing the risk of intracranial aneurysm
	promoter polymorphism (-1385 A/G) was significantly associated with AD risk
	SNP rs152524 was associated in a dose-dependent manner with systolic Blood pressure

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     mutant R50E suppressed tumor growth while WT FGF1 enhanced it using cancer cells that stably express WT FGF1 or R50E cardiovascular atheroma   FGF1/MAPK14 inhibitor therapy induces cardiomyocyte mitosis, reduces scarring, and rescues function after myocardial infarction

ANIMAL & CELL MODELS

Fgf1 is highly induced in adipose tissue in response to high-fat diet (HFD) and mice lacking Fgf1 develop an aggressive diabetic phenotype coupled to aberrant adipose expansion when challenged with HFD