protein
| PSMC5-leading to proteasome-dependent degradation of SP1, AP2 |
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TAF4 and HO |
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functional synergy of SP1, SP3, SP4 with the photoreceptor-enriched CRX transcriptional regulator on the rod opsin promoter but not the beta-PDE promoter, although SP4-mediated activation was the most significant |
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interacts with POGZ, HCFC1, AATF and PHC2 |
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interacts with varicella-zoster virus ie62 protein and HIV-1 vpr |
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interacting with FGFR1 (necessary positive regulator of FGFR1 gene transcription in neonatal cardiomyocytes) |
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interacting with ZBTB2 |
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binds GC-rich motifs with high affinity and can regulate the expression of TATA-containing and TATA-less genes via protein-protein interactions or interplay with other transcription factors such as Ets-1, c-myc, c-Jun, Stat1 and Egr-1 |
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CDX2 and SP1 can activate the ELMO3 promoter |
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CREB1, SP1, and TFAP4 play roles in modulating PPP2R2B expression |
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direct interaction with the transport factor importin alpha, not importin beta (SP1 requires all three zinc finger for the nucleus localization, and it is indispensable in the interaction with importin alpha) |
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activates DOK7 gene expression through interaction with these two SP1 sites |
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critical regulator of the CTH expression during smooth muscle cells differentiation |
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plays an important role in regulation of Kindlin-2 (FERMT2) expression (PMI: 21922223) |
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PLAGL1 might serve as an SP1-like protein that directly interacts with the SP1-responsive element to oligomerize with and/or to coactivate SP1 |
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bound to the CTSE promoter region, and SP1 binding plays potentially a particularly important role in the regulation of CTSE gene expression |
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promoter of SERPINA3 is transcriptionally activated by three transcription factors (TFs) (SP1, MZF1 and ZBTB7B) |
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binds to the MFN2 promoter and its overexpression activates the MFN2 promoter in vascular smooth muscle cells) ( |
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is a major regulator of periodic expression of CKAP2, and cell-cycle-dependent phosphorylation of SP1 mediated by CCNA2 can regulate the DNA-binding affinity of SP1 |
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basal expression level of IRF3 is regulated by transcription factors SP1 and SP3 |
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crucial role of SP1 in the regulation of CEP131 gene transcription |
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interaction between accumulated preLMNA and SP1 transcription factor, results in altered extracellular matrix gene expression, impairing adipogenesis |
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NR1D1 activates GJA1 transcription by forming a complex with SP1 |
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SP1 is a fundamental activator of basal SYN1 gene expression, whose activity is modulated by the neural master regulator REST and CpG methylation |
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strict functional interplay between SP1 and REST, which exerts a dominant negative role on SP1 function and chromatin affinity on the SYN1 promoter |
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SP1 may significantly affect the number of EPOR molecules present on the surface of activated CD4(+) lymphocytes |
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FUT4 is a target gene for HSF1 and SP1 that is required for cell cycle progression in breast cancer epithelial cells |
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SP1 and SP3 are functionally involved as transcriptional integrators regulating the basal expression of the derived EPHX1 E1b variant transcript |
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SP1/SP3 transcription factors trigger MINA expression through additive activity targeted to a cluster of four SP1/SP3 binding sites forming the P1 promoter |
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EPAS1 plays an indispensible role in SP1 transcription factor-mediated ZBTB7A induction, and participated in tumor cell survival and proliferation |
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MALAT1 directly interacted with SP1 and LTBP3 promoter to increase expression of LTBP3 gene |
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CTCFL and Sp1 have opposite effects on the regulation of MAGEA1 gene expression |
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GATA2, SP1 and TATA-binding protein (TBP)interacting with the proximal promoter region of MAOA |
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SENP3 regulates the global protein turnover and the SP1 level via antagonizing SUMO2/3-targeted ubiquitination and degradation |
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SP1 transcription factor is the primary determinant for activating the basal transcription of the IRF5 |
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SP1-induced upregulation of long non-coding RNA HCP5 promotes the development of osteosarcoma |
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binding of LGALS3 to MUC1 enhances likely the recruitment of SP1, leading to promotion of the transcription of TACSTD2 |