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FLASH GENE
Symbol NR2F1 contributors: npt/mct/shn - updated : 12-03-2014
HGNC name nuclear receptor subfamily 2, group F, member 1
HGNC id 7975
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal gland    
 adrenal glandmedulla   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal modulating domain
  • a central bipartite zinc finger
  • DNA binding domain
  • a C terminal ligand domain
  • HOMOLOGY
    interspecies ortholog to Nr2f1, Mus musculus
    ortholog to Nr2f1, Rattus norvegicus
    ortholog to NR2F1, Pan troglodytes
    Homologene
    FAMILY
  • steroid/thyroid hormone receptor superfamily
  • steroid receptor superfamily
  • CATEGORY regulatory , transcription factor , protooncogene , receptor nuclear
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • nuclear receptor involved in the organogenesis
  • required for the formation of commissural projections in the forebrain by regulating axonal growth (Armentano 2006)
  • orphan nuclear receptor promoting ventral cortical fate, cell cycle exit and neural differentiation, regulating the balance of early- and late-born neurons, and the balanced production of different types of layer V cortical projection neurons (Faedo 2008)
  • action regulation of the transcription of GNRH1
  • transcription factor binded to the ovalbumin promoter and, in conjunction with another protein stimulating initiation of transcription
  • central role in the induction of the TNFAIP8 promoter by TNFalpha (Zhang 2009)
  • with NR2F2 play roles in amacrine cell differentiation (Inoue 2010)
  • controls the timing of birth and specification of corticospinal motor neurons (CSMN) in somatosensory cortex via repression of a CSMN differentiation program (Tomassy 2010)
  • exerts critical areal and temporal control over the precise differentiation of corticospinal motor neurons during corticogenesis, thereby enabling the area-specific functional features of motor and sensory areas to arise (Tomassy 2010)
  • directly represses Rnd2 expression at the post-mitotic level along the rostrocaudal axis of the mouse neocortex
  • modulates late-born neuron migration and favours proper differentiation of late-born callosal projection neurons by finely regulating Rnd2 expression levels
  • suppresses synergistic activation of the MTTP promoter by HNF4A/HNF1A by binding to a direct repeat 1 (DR1) element
  • regulator of cortical development known to collaborate with retinoic acid (RA) signaling in other systems
  • role in the adult brain as a key regulator in the control of sensory-dependent plasticity in olfactory dopaminergic neurons
  • has an important role in the development of the visual system and that haploinsuffiency can lead to optic atrophy with intellectual impairment
  • CELLULAR PROCESS nucleotide, replication
    PHYSIOLOGICAL PROCESS
    text neurotransmitter receptor
    PATHWAY
    metabolism
    signaling
    a component novel NR2FI complex with TNFAIP8 that functions as a repressor of transcription and may play a role in the TNFalpha signaling pathways (Zhang 2009)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • retinoid X receptor, RXR
  • S300-II/TFIIB
  • Sp1
  • estrogen receptor, ER
  • Alien
  • aryl hydrocarbon receptor, AHR
  • GRIP1 and SRC-1
  • human estrogen receptor alpha, hER alpha
  • Thyroid hormone receptor, TR
  • NR2F1 and ERN2 suppress MTTP expression and lipoprotein assembly in undifferentiated intestinal epithelial cell
  • may be an important factor to modulate expression of genes that are repressed by T(3)
  • expression of RND2, a modulator of radial migration, is complementary to both these gradients and strongly increases in the absence of NR2F1 function
  • involved in the regulatory modulation of the expression of at least two genes, CYP26A1 and HOXA1
  • cell & other
    REGULATION
    activated by transcriptionally activated by all-trans retinoic acid (RA)
    ASSOCIATED DISORDERS
    corresponding disease(s) OAID
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • COUP-TFI mutant mice late-born callosal projection neurons are delayed in reaching the cortical plate and have morphological defects during migration
  • axonal elongation and dendritic arborization are impaired in late-born callosal projection neurons of mouse COUP-TFI-deficient