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FLASH GENE

Symbol

ETS2

contributors: mct/npt/shn - updated : 04-12-2015

HGNC name	v-ets avian erythroblastosis virus E26 oncogene homolog 2
HGNC id	3489

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	mice with less than 2-fold Ets2 overexpression in particular organs develop neurocranial, viscerocranial and cervical skeletal abnormalities
	ETS2 overexpression transgenic mouse develops a smaller thymus and lymphocyte abnormalities
	Inactivation of Ets2 results in mouse trophoblast stem (TS) cell slower growth, increased expression of a subset of differentiation-associated genes and decreased expression of several genes implicated in TS self-renewal