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FLASH GENE
Symbol ETS2 contributors: mct/npt/shn - updated : 04-12-2015
HGNC name v-ets avian erythroblastosis virus E26 oncogene homolog 2
HGNC id 3489
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a DNA-binding domain at the N-terminus and a repression domain at the C-terminus
    • HOMOLOGY
    interspecies homolog to avian erythroblastosis virus E26 (v-ets) oncogene 2
    ortholog to Ets2, Mus musculus
    ortholog to Ets2, Rattus norvegicus
    ortholog to ets2, Danio rerio
    ortholog to ETS2, Pan troglodytes
    Homologene
    FAMILY
  • ETS family
    • CATEGORY transcription factor , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • transcription regulator, activating stromelysin-1 (MMP3) collagenase 1 (MMP8), and CDKN2A promoters
  • a role in skeletal development
  • likely involved in skeletal development and required to maintain the transformed state of human prostate cancer cells (role with TP53 in pathological processes of oncogenesis)
  • transcriptional regulator of beta-APP playing a role in the regulation of neuronal apootosis and in the brain pathology of Down syndrome
  • essential for trophoblast stem (TS) cells self-renewal
  • key regulatory factor in the transcriptional control of DUSP6 in responding to activity of MAPK1 (Furukawa 2008)
  • essential for the normal progression of the adipocyte differentiation program in vitro and is a transcription factor in adipogenesis
  • ETS2 has a critical role in directing cardiac progenitors during cardiopoiesis in embryonic stem cells
  • ETS2 and MESP1 play important roles in a genetic network that governs cardiopoiesis
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
  • interleukin-5 promoter
  • -10 Ets element PS1 promoter
    • RNA
    small molecule
    protein
  • p300/cAMP-responsive element-binding protein
  • STAT5
  • glucocorticoid receptor, GR
  • Cdk10
  • Brg-1, BAF57/p50 and Ini1
  • EAPII
  • co-repressor BS69
  • Ets-1, SRC-1 and AIB1
  • CDK10 is a protein kinase that partners with CCNQ to phosphorylate substrates such as ETS2 and PKN2 in order to modulate cellular growth
    • cell & other
    REGULATION
    Other ID1 inhibits CDKN2A activation by ETS2 (and ETS1)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice with less than 2-fold Ets2 overexpression in particular organs develop neurocranial, viscerocranial and cervical skeletal abnormalities
  • ETS2 overexpression transgenic mouse develops a smaller thymus and lymphocyte abnormalities
  • Inactivation of Ets2 results in mouse trophoblast stem (TS) cell slower growth, increased expression of a subset of differentiation-associated genes and decreased expression of several genes implicated in TS self-renewal