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FLASH GENE
Symbol ETS2 contributors: mct/npt/shn - updated : 04-12-2015
HGNC name v-ets avian erythroblastosis virus E26 oncogene homolog 2
HGNC id 3489
DNA
TYPE functioning gene
STRUCTURE 19.03 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status confirmed
Map cen - D21S1883 - D21S1255 - ETS2 - D21S1891 - D21S268 - qter
Authors Hubert (97), Vidal-Taboada (98)
Text [ ]:DSCR2 critical region
RNA
TRANSCRIPTS type messenger
text promoter region of ETS2 does not possess typical "TATA" and "CAAT" elements but contains several repeat regions, two consensus AP2 binding sites and three putative Sp1 sites PMID:2405393
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 splicing 3684 - 469 - -
10 splicing 3954 - 609 - -
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
cell lineage
cell lines HL60, HeLa, K562, Mott4, B.L.Raji, SW48, A549, G361
fluid/secretion
at STAGE
physiological period embryo
Text endocardium, endothelium
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a DNA-binding domain at the N-terminus and a repression domain at the C-terminus
    • HOMOLOGY
    interspecies homolog to avian erythroblastosis virus E26 (v-ets) oncogene 2
    ortholog to Ets2, Mus musculus
    ortholog to Ets2, Rattus norvegicus
    ortholog to ets2, Danio rerio
    ortholog to ETS2, Pan troglodytes
    Homologene
    FAMILY
  • ETS family
    • CATEGORY transcription factor , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • transcription regulator, activating stromelysin-1 (MMP3) collagenase 1 (MMP8), and CDKN2A promoters
  • a role in skeletal development
  • likely involved in skeletal development and required to maintain the transformed state of human prostate cancer cells (role with TP53 in pathological processes of oncogenesis)
  • transcriptional regulator of beta-APP playing a role in the regulation of neuronal apootosis and in the brain pathology of Down syndrome
  • essential for trophoblast stem (TS) cells self-renewal
  • key regulatory factor in the transcriptional control of DUSP6 in responding to activity of MAPK1 (Furukawa 2008)
  • essential for the normal progression of the adipocyte differentiation program in vitro and is a transcription factor in adipogenesis
  • ETS2 has a critical role in directing cardiac progenitors during cardiopoiesis in embryonic stem cells
  • ETS2 and MESP1 play important roles in a genetic network that governs cardiopoiesis
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
  • interleukin-5 promoter
  • -10 Ets element PS1 promoter
    • RNA
    small molecule
    protein
  • p300/cAMP-responsive element-binding protein
  • STAT5
  • glucocorticoid receptor, GR
  • Cdk10
  • Brg-1, BAF57/p50 and Ini1
  • EAPII
  • co-repressor BS69
  • Ets-1, SRC-1 and AIB1
  • CDK10 is a protein kinase that partners with CCNQ to phosphorylate substrates such as ETS2 and PKN2 in order to modulate cellular growth
    • cell & other
    REGULATION
    Other ID1 inhibits CDKN2A activation by ETS2 (and ETS1)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice with less than 2-fold Ets2 overexpression in particular organs develop neurocranial, viscerocranial and cervical skeletal abnormalities
  • ETS2 overexpression transgenic mouse develops a smaller thymus and lymphocyte abnormalities
  • Inactivation of Ets2 results in mouse trophoblast stem (TS) cell slower growth, increased expression of a subset of differentiation-associated genes and decreased expression of several genes implicated in TS self-renewal