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FLASH GENE

Symbol

EN1

contributors: mct - updated : 27-03-2019

HGNC name	engrailed homeobox 1
HGNC id	3342

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   deletion     repression of the entire 4-Mb band of chromosome 2q.14.2, associated with global methylation of histone H3 Lys9 in colorectal cancer tumoral     --other   expressed focally in the epidermal neoplasms of seborrheic keratosis and squamous cell carcinoma constitutional         causes mispatterning of the forelimb and thus defects in the dorsal-ventral pathfinding choice of motor axons

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

En1 knockout mice