| basic FUNCTION
| regulator of the ventral limb patterning |
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inhibiting WNT7A expression in ventral limb bud |
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involved in transcriptional and translational modulation |
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seems to be capable of acting as a morphogen in its own right |
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EN1, EN2 represent a new class of genes that are fundamental to patterning cerebellum foliation throughout the mediolateral axis and that act late in development  |
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EN1, EN2 are required for patterning the morphological and molecular domains along both axes, as well as for the establishment of the normal afferent topography required to generate a fully functional cerebellum |
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functions upstream of FGFR2 in regulating early calvarial osteogenic differentiation, and likely it plays an additional role in precluding premature osteogenic conversion of the sutural mesenchyme |
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EN1 and EN2 have overlapping functions in the cells derived from each progenitor zone in regulating formation of additional fissures and for extensive cerebellar growth |
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is an activator of intrinsic inflammatory pathways associated with prosurvival in basal-like breast cancer |
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expressed in the ventral ectoderm of the developing limb where it plays an instructive role in the dorsal-ventral patterning of the forelimb (PMUID: 25710467) |
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EN1 but not EN2 has a direct and specific repulsive effect on motor axons of the lateral aspect of the lateral motor column (LMC) but not on medial LMC projections |
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important roles for EN1 in the development and maturation of a diverse group of brainstem auditory neurons |
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is a gene important for ventral nuclei of the lateral lemniscus (VNLL) neuron development and survival |
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regulated levels of PITX3 and EN1 control the size and rostral/caudal-identity of the Mesodiencephalic dopaminergic (mdDA) neuronal population |
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plays an important role in the regionalization of the neural tube |
