| basic FUNCTION
| regulator of cell proliferation |
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plays a crucial role in mitogenic regulation of human brain tumor stem cells  |
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differentiation of specific cells and mitogenic factor for cells of ectodermal and mesodermal origin |
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antagonistically involved in both PTK2 phosphorylation and dephosphorylation with different mechanisms in a cell |
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EGF and FGF2, may play an important role in the fate decision of neural crest progenitors and in the development of the peripheral nervous system |
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activates ERBB1/ERBB1 or ERBB1/ERBB2 dimers |
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caspase-8 is necessary for the efficient activation of downstream events associated with epidermal growth factor (EGF) signaling |
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EGF with nucleotides carry the potential to act synergistically in the control of cell proliferation and cell survival in adult neurogenesis |
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EGF and TGFA retain some level of functional redundancy, possibly resulting from their divergence from a common ancestral gene |
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inhibits SLC9A8 gene expression through reducing its basal transcription, suggesting an important role of EGF in regulating SLC9A8 expression during intestinal maturation) |
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involved in nervous system development |
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EGF-induced cell migration is mediated by the lipase domain of PLCG1 and the subsequent IP(3) generation and intracellular calcium mobilization |
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promotes breast cancer tumour growth and survival, rapidly induces SERPINE1 expression in the breast adenocarcinoma cell line |
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crucial regulatory mechanism for EGF in GFER transcription within the promoter proximal region |
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IGF1 and epidermal growth factor (EGF) play important roles in the regulation of cell metabolism in response to different internal as well as external stimuli |
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may play a role in the function of the endocrine pancreas and in the pathogenesis of the diabetes mellitus |
