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FLASH GENE

Symbol

EGF

contributors: mct/ - updated : 08-04-2011

HGNC name	epidermal growth factor
HGNC id	3229

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	HOMG4 hypomagnesemia, renal
Location	4q25      Physical location : 110.834.039 - 110.934.117
Synonym name	urogastrone
	epidermal growth factor (beta-urogastrone)
	pro-epidermal growth factor
Synonym symbol(s)	URG, HOMG4

DNA

TYPE	functioning gene
STRUCTURE	100.08 kb     24 Exon(s)

10 Kb 5' upstream gene genomic sequence study

text structure

cis-regulatory elements with a Y-box sequence 5' - CTGATTGG - 3'

MAPPING

cloned

Y

linked

Y

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001178130 23 - 5477 NP_001171601 - 1166 - 1995 7640657 NM_001178131 23 - 5474 NP_001171602 - 1165 - 1995 7640657 NM_001963 24 - 5600 NP_001954 2.4 1207 - 1995 7640657

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine duodenum       mouth           salivary gland submandibular       Nervous spinal cord       highly Respiratory respiratory tract trachea     highly Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal   highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	containing nine EGF-like repeats
	nine LDL-receptor class b repeats

conjugated

GlycoP

isoforms

Precursor

mature peptide of 53AA

HOMOLOGY

Homologene

FAMILY

epidermal growth factor family

CATEGORY

signaling cytokine growth factor

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
	intracellular
	intracellular,nucleus
text	precursor membrane bound

basic FUNCTION	regulator of cell proliferation
	plays a crucial role in mitogenic regulation of human brain tumor stem cells
	differentiation of specific cells and mitogenic factor for cells of ectodermal and mesodermal origin
	antagonistically involved in both PTK2 phosphorylation and dephosphorylation with different mechanisms in a cell
	EGF and FGF2, may play an important role in the fate decision of neural crest progenitors and in the development of the peripheral nervous system
	activates ERBB1/ERBB1 or ERBB1/ERBB2 dimers
	caspase-8 is necessary for the efficient activation of downstream events associated with epidermal growth factor (EGF) signaling
	EGF with nucleotides carry the potential to act synergistically in the control of cell proliferation and cell survival in adult neurogenesis
	EGF and TGFA retain some level of functional redundancy, possibly resulting from their divergence from a common ancestral gene
	inhibits SLC9A8 gene expression through reducing its basal transcription, suggesting an important role of EGF in regulating SLC9A8 expression during intestinal maturation)
	involved in nervous system development
	EGF-induced cell migration is mediated by the lipase domain of PLCG1 and the subsequent IP(3) generation and intracellular calcium mobilization
	promotes breast cancer tumour growth and survival, rapidly induces SERPINE1 expression in the breast adenocarcinoma cell line
	crucial regulatory mechanism for EGF in GFER transcription within the promoter proximal region
	IGF1 and epidermal growth factor (EGF) play important roles in the regulation of cell metabolism in response to different internal as well as external stimuli
	may play a role in the function of the endocrine pancreas and in the pathogenesis of the diabetes mellitus

CELLULAR PROCESS	cell life, differentiation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	Ca2+

protein	stimulating histone H3 phosphorylation,RSK2 dependent
	rapidly depolymerizing actin and inducing formation of membrane ruffles
	activating phospholipase D1b
	cooperation between the EGF/EGFR and PTGES leads to a significant tumorigenic gain in epithelial cells
	EGF controls the levels of CLDN2 and CLDN4 proteins and mRNAs through SRC and STAT3 activity

cell & other

protecting microtubules assembly of F-actin cytoskeleton and intestinal barrier integrity against oxidant injury, PRKZ dependent

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

HOMG4

Susceptibility

to extraaxial nervous system tumors

Variant & Polymorphism other	A61G polymorphism can be associated with susceptibility to development of extraaxial nervous system tumors but not with overall survival

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS